N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
CAS No.:1616380-54-1
Molecular Formula:C₂₃H₂₄FN₅O₄
Molecular Weight:453.473
Hs Code.:

Synonyms:N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Suppliers and Price of N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

There total 8 articles about N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-53-0
N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1616380-54-1
N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: In dichloromethane; at -30 ℃; for 0.666667h;

Reference yield:

: 4-[(2-methoxyethoxy)methoxy]aniline

: 1616380-54-1
N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 24 h / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / 3620.13 Torr / Inert atmosphere; Autoclave

3: dichloromethane / 0.67 h / -30 °C

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol; dichloromethane;

Reference yield:

: 575474-26-9
2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine

: 1616380-54-1
N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 24 h / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / 3620.13 Torr / Inert atmosphere; Autoclave

3: dichloromethane / 0.67 h / -30 °C

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol; dichloromethane;