575474-26-9

Basic information

• Product Name: 2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine
• Synonyms: 2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine
• CAS NO: 575474-26-9
• Molecular Weight: 268.635
• Mol File: 575474-26-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine(575474-26-9)
• EPA Substance Registry System: 2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine(575474-26-9)

Safety Data

• Hazardous Substances Data: 575474-26-9(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 1202760-28-8 C₁₆H₁₃FN₆O₄S 
• 1202760-20-0 C₂₄H₂₇FN₆O₅ 
• 1202760-75-5 C₃₂H₄₂F₂N₆O₆Si 
• 1616380-52-9 5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine 
• 1616380-92-7 tert-butyl (2-chloro-5-fluoropyrimidin-4-yl)(3-(hydroxyamino)phenyl)carbamate 
• 1616380-93-8 tert-butyl (2-chloro-5-fluoropyrimidin-4-yl)(3-(N-hydroxyacrylamido)phenyl)carbamate 
• 1616380-94-9 tert-butyl (5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)(3-(N-hydroxyacrylamido)phenyl)carbamate 
• 1616380-33-6 N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-hydroxyacrylamide 
• 1616380-53-0 N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine 
• 1616380-54-1 N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide 
• 1616380-28-9 N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide 
• 1616380-30-3 N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide 
• 1616381-19-1 N-{3-[(2-chloro-5-fluoropyrimidin-4-yl)amino]phenyl}prop-2-enamide 
• 1202760-79-9 C₃₅H₄₆F₂N₆O₅Si 

Relevant articles and documents

Synthesis, Biological Activity of Pyrimidine Linked with Morpholinophenyl Derivatives

A new series of 5-fluoro-N4-(3-(4-substitutedbenzylamino)phenyl)-N2-(4-morpholinophenyl)pyrimidine-2,4-diamine derivatives (7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j) are prepared from using an intermediate compound 5-fluoro-N4-(3-(aminophenyl)-N2-(4-morpholinophenyl)pyrimidine-2,4-diamine (5). The structures of the newly synthesized products are established from their spectral1H-NMR,13C-NMR,19F-NMR, ESI-MS, and analytical data. Here we report the synthesized compounds and larvicidal activity. All the compounds are screened for their significant larvicidal activity against third instar larvae at 24, 48, and 78-h time exposure, and values were compared with standard drug Malathion. The Compounds 7i, 7a, 7c, 7f, and 7j exhibited significant activity. However the compounds 7b, 7e, 7d, and 7h showed excellent activity when compared to the above compounds and to standard drug malathion too because of the presence of mild electron withdrawing groups such as trifluoro, fluorine, hydroxy, nitro, and methoxy derivatives which are attached to the benzyl ring.

PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF

Provided herein are pentafluorobenzenesulfonamide compounds of Formula (I), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases. These compounds are covalent small molecule inhibitors,

Dithiocarbamate type compound used as BTK (Bruton Tyrosine Kinase) inhibitor

The invention aims at providing a dithiocarbamate type compound used as a BTK (Bruton Tyrosine Kinase) inhibitor and a pharmaceutical composition thereof, a preparation method and application. The compound provided by the invention has a structure shown as a general formula (I). The formula (I) is shown in the description.