1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

Base Information

Chemical Name:1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole
CAS No.:205238-35-3
Molecular Formula:C₁₈H₁₇NO₂S
Molecular Weight:311.404
Hs Code.:

Synonyms:1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

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Chemical Property of 1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

Chemical Property:

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Technology Process of 1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

There total 9 articles about 1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80360-14-1
3-iodo-1-phenylsulfonyl-1H-indole

: 205238-35-3
1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / Pd(OAc)2, Ph₃P, n-Bu₄NCl, KOAc / dimethylformamide / 80 °C

2: 53 percent / O₃, sodium borohydride / ethanol / -78 - 0 °C

3: 82 percent / lipase AK / benzene / Ambient temperature

4: 90 percent / Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

5: 1.) NaBH₄; 2.) lithium aluminum hydride / 1.) DMSO, 60 deg C; 2.) THF, 0 deg C

6: 87 percent / i-Pr₂NEt, 4-DMAP / Ambient temperature

7: 94 percent / 18-crown-6 / dimethylsulfoxide / 60 °C

8: 1.) diisobutylaluminum hydride; 2.) 10percent HCl / CH₂Cl₂; hexane

9: NaBH₄ / methanol / 0 °C

10: 1.) o-nitrophenylselenylcyanide, tri-n-butylphosphine; 2.) hydrogen peroxide / 1.) THF, r.t.; 2.) THF, r.t.

With hydrogenchloride; dmap; palladium diacetate; sodium tetrahydroborate; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; lipase AK; 18-crown-6 ether; tributylphosphine; tetrabutyl-ammonium chloride; dihydrogen peroxide; potassium acetate; diisobutylaluminium hydride; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.3987/com-97-s39

Reference yield:

: 205238-32-0
(S)-3-(1-Benzenesulfonyl-1H-indol-3-yl)-butyronitrile

: 205238-35-3
1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) diisobutylaluminum hydride; 2.) 10percent HCl / CH₂Cl₂; hexane

2: NaBH₄ / methanol / 0 °C

3: 1.) o-nitrophenylselenylcyanide, tri-n-butylphosphine; 2.) hydrogen peroxide / 1.) THF, r.t.; 2.) THF, r.t.

With hydrogenchloride; sodium tetrahydroborate; ortho-nitrophenyl selenocyanate; tributylphosphine; dihydrogen peroxide; diisobutylaluminium hydride; In methanol; hexane; dichloromethane;
DOI:10.3987/com-97-s39

Reference yield:

: 205238-29-5
2-(1-Benzenesulfonyl-1H-indol-3-yl)-propane-1,3-diol

: 205238-35-3
1-Benzenesulfonyl-3-((S)-1-methyl-allyl)-1H-indole

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / lipase AK / benzene / Ambient temperature

2: 90 percent / Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) NaBH₄; 2.) lithium aluminum hydride / 1.) DMSO, 60 deg C; 2.) THF, 0 deg C

4: 87 percent / i-Pr₂NEt, 4-DMAP / Ambient temperature

5: 94 percent / 18-crown-6 / dimethylsulfoxide / 60 °C

6: 1.) diisobutylaluminum hydride; 2.) 10percent HCl / CH₂Cl₂; hexane

7: NaBH₄ / methanol / 0 °C

8: 1.) o-nitrophenylselenylcyanide, tri-n-butylphosphine; 2.) hydrogen peroxide / 1.) THF, r.t.; 2.) THF, r.t.

With hydrogenchloride; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; lipase AK; 18-crown-6 ether; tributylphosphine; dihydrogen peroxide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; hexane; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.3987/com-97-s39