N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

Base Information

Chemical Name:N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide
CAS No.:1254205-46-3
Molecular Formula:C₂₀H₁₆ClF₃N₂O₃S
Molecular Weight:456.873
Hs Code.:

Synonyms:N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

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Chemical Property of N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

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Technology Process of N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

There total 7 articles about N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1254205-44-1
4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid

: 1254205-46-3
N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

Guidance literature:: 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 18 - 25 ℃; for 0.5h;

With water; sodium hydroxide; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1254207-06-1
methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

: 1254205-46-3
N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2014.10.074

Reference yield:

: 69812-51-7
4-chlorosulfonyl-benzoic acid methyl ester

: 1254205-46-3
N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 80 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; sodium hydride; caesium carbonate; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.10.074