methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Base Information

• Chemical Name: methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate
• CAS No.: 1254207-06-1
• Molecular Formula: C₂₁H₁₆ClF₃N₂O₄S
• Molecular Weight: 484.883

Synonyms:methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Chemical Property of methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

There total 6 articles about methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-05-0) + benzyl bromide (100-39-0) → methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-06-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 18 ℃; Reflux;

Reference yield:

methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-05-0) → methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-06-1)

Guidance literature:

With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.bmcl.2014.10.074

Reference yield:

methyl 4-(N-benzylsulfamoyl)benzoate (1241472-90-1) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → methyl 4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate (1254207-06-1)

Guidance literature:

With caesium carbonate; In acetonitrile; at 160 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.10.074

upstream raw materials:

methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

benzyl bromide

2-amino-3-chloro-5-(trifluoromethyl)pyridine

benzylamine

Downstream raw materials:

4-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid

N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(hydroxymethyl)benzene-1-sulfonamide

4-(benzyl(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzamide

4-(benzyl(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)-N-methylbenzamide

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