(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

Base Information

Chemical Name:(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol
CAS No.:177932-58-0
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

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Chemical Property of (3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

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Technology Process of (3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

There total 7 articles about (3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 177932-57-9
(3aS,6R,7aR)-2-Benzyl-6-methyl-octahydro-isoindol-4-one

: 31600-86-9
2-methoxyphenyllithium

: 177932-58-0
(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

Guidance literature:: With lithium bromide; at -78 ℃; for 2h;
DOI:10.1016/S0040-4039(00)00555-4

Reference yield:

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 177932-58-0
(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 4.1 g / quinine / CH₂Cl₂ / 12 h / -78 - -20 °C

2: 93 percent / imidazole / dimethylformamide / 12 h / 60 °C

3: 48 percent / AlH₃ / tetrahydrofuran / 2 h / -78 °C

4: 74 percent / NaIO₄ / tetrahydrofuran; H₂O / 12 h / 0 °C

5: 48 percent / tetrahydrofuran / 2 h / -78 °C

6: 46 percent / tetrahydrofuran / 48 h / Heating

7: 93 percent / n-Bu₃SnH; AIBN / toluene / 2 h / Heating

8: 62 percent / LiBr / 2 h / -78 °C

With 1H-imidazole; aluminium hydride; sodium periodate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium bromide; Quinine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Diels-Alder reaction / 2: silylation / 3: Reduction / 4: Oxidation / 5: Grignard reaction / 6: Substitution / 7: Reduction / 8: Addition;
DOI:10.1016/S0040-4039(00)00555-4

Reference yield:

: 289041-21-0
(3aS,6S,7S,7aR)-2-Benzyl-7-hydroxy-6-methyl-octahydro-isoindol-4-one

: 177932-58-0
(3aS,4S,6R,7aR)-2-Benzyl-4-(2-methoxy-phenyl)-6-methyl-octahydro-isoindol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / tetrahydrofuran / 48 h / Heating

2: 93 percent / n-Bu₃SnH; AIBN / toluene / 2 h / Heating

3: 62 percent / LiBr / 2 h / -78 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium bromide; In tetrahydrofuran; toluene; 1: Substitution / 2: Reduction / 3: Addition;
DOI:10.1016/S0040-4039(00)00555-4