5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one
CAS No.:1352570-71-8
Molecular Formula:C₂₃H₂₃N₃O₅S
Molecular Weight:453.519
Hs Code.:

Synonyms:5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

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Chemical Property of 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

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Technology Process of 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

There total 5 articles about 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1352571-45-9
(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

: 1352570-71-8
5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; under 2068.65 Torr;

Reference yield:

: 50765-21-4
3-hydroxy-5-iodobenzoic acid

: 1352570-71-8
5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 2068.65 Torr

With hydrogen; potassium acetate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 4.1: Suzuki Coupling;

Reference yield:

: 1366240-08-5
(3-hydroxy-5-iodophenyl)(pyrrolidin-1-yl)methanone

: 1352570-71-8
5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 2068.65 Torr

With hydrogen; potassium acetate; sodium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 3: Suzuki Coupling;