(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone
CAS No.:1352571-45-9
Molecular Formula:C₃₀H₂₉N₃O₅S
Molecular Weight:543.643
Hs Code.:

Synonyms:(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

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Chemical Property of (3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

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Technology Process of (3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

There total 4 articles about (3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1366240-68-7
4-(benzyloxy)-2-chloro-5-methylpyrimidine

: 1352571-44-8
(3-(4-(methylsulfonyl)phenoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(pyrrolidin-1-yl)methanone

: 1352571-45-9
(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; toluene; at 80 ℃; Inert atmosphere;

Reference yield:

: 50765-21-4
3-hydroxy-5-iodobenzoic acid

: 1352571-45-9
(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere

With potassium acetate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 4.1: Suzuki Coupling;

Reference yield:

: 1366240-08-5
(3-hydroxy-5-iodophenyl)(pyrrolidin-1-yl)methanone

: 1352571-45-9
(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere

With potassium acetate; sodium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 3: Suzuki Coupling;