(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Base Information

Chemical Name:(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide
CAS No.:168158-21-2
Molecular Formula:C₂₄H₃₁N₃O₄
Molecular Weight:425.528
Hs Code.:

(R)-N<sup>4</sup>-Benzyloxy-2-isobutyl-N<sup>1</sup>-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Synonyms:(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Suppliers and Price of (R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Chemical Property:

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Technology Process of (R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

There total 3 articles about (R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5491-18-9,17609-52-8,53990-33-3,60584-76-1
(S)-N-(benzyloxycarbonyl)phenylglycine

: 168158-21-2
(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ethyl chloroformate, Et₃N / 1.) THF, 5 deg C, 2.) THF, MeOH, 2 h

2: H₂ / 10percent Pd/C / methanol / 2942.03 Torr / Ambient temperature

3: (1-(3-dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

With hydrogen; chloroformic acid ethyl ester; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

: 168158-22-3
Z-L-phenylglycine methyl amide

: 168158-21-2
(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 2942.03 Torr / Ambient temperature

2: (1-(3-dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

: 129213-83-8
(S)-2-amino-N-methyl-2-phenylacetamide

: 4--2(R)-isobutylsuccinic acid

: 168158-21-2
(R)-N⁴-Benzyloxy-2-isobutyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; Yield given; Ambient temperature;
DOI:10.1016/S0968-0896(97)00028-X