129213-83-8

Basic information

• Product Name: (S)-2-amino-N-methyl-2-phenylacetamide
• Synonyms: (S)-2-amino-N-methyl-2-phenylacetamide
• CAS NO: 129213-83-8
• Molecular Weight: 164.207
• Mol File: 129213-83-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-N-methyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-N-methyl-2-phenylacetamide(129213-83-8)
• EPA Substance Registry System: (S)-2-amino-N-methyl-2-phenylacetamide(129213-83-8)

Safety Data

• Hazardous Substances Data: 129213-83-8(Hazardous Substances Data)

Upstream product

• 1033883-20-3 (S)-tert-butyl 2-(methylamino)-2-oxo-1-phenylethylcarbamate 
• 875-74-1 (R)-phenylglycine 
• 108-86-1 bromobenzene 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 74-89-5 methylamine 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 
• 146118-22-1 Z-PhGly-OSu 
• 2935-35-5 (S)-2-phenylglycine 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 744949-71-1 D-(-)-α-phenylglycylchloride 
• 168158-22-3 Z-L-phenylglycine methyl amide 
• 15962-49-9 (S)-phenylglycine ethyl ester 
• 59410-82-1 (S)-α-phenylglycine ethyl ester hydrochloride 

Downstream Products

• 871917-48-5 L-isoleucyl-L-phenylglycine methyl amide 
• 129155-86-8 (S)-2-Hydroxyamino-N-methyl-2-phenyl-acetamide 
• 129155-82-4 (S)-1-Hydroxy-2-(4-methoxy-phenyl)-3-methyl-5-phenyl-imidazolidin-4-one 
• 1094091-94-7 C₂₂H₂₈BrN₅O₄ 
• 97443-96-4 (2S,5R)-2-(tert-Butyl)-3-methyl-5-phenylimidazoldin-4-on 
• 61337-91-5 (R)-N¹-methyl-1-phenylethane-1,2-diamine 
• 1383925-63-0 (R)-(+)-1-methyl-4-phenyl-2-(pyrid-2-yl)imidazoline 
• 126180-07-2 (R)-N-methyl(phenyl)<(R)-2-vinylpyrrolidin-1-yl>acetamide 
• 126179-95-1 (R)-N-methyl(phenyl)<(S)-2-vinylpyrrolidin-1-yl>acetamide 
• 126180-08-3 N-<(R)-α-N-methyl(aminomethyl)benzyl>-(R)-2-vinylpyrrolidine 
• 126179-96-2 N-<(R)-α-N-methyl(aminomethyl)benzyl>-(S)-2-vinylpyrrolidine 
• 126179-90-6 (R)-N-methyl-2-(N'-hexa-4,5-dienylamino)-2-phenylacetamide 
• 126179-91-7 (R)-N-hexa-4,5-dienyl-N-methyl-1-phenyldimethylene diamine 
• 168158-38-1 (2R,3S)-N⁴-Benzyloxy-2-isobutyl-3-methyl-N¹-((S)-methylcarbamoyl-phenyl-methyl)-succinamide 

Relevant articles and documents

A Concise Enantiodivergent Synthesis of Equol

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan's α-Arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, respectively).

The asymmetric reduction of imidazolinones with trichlorosilane

It is shown how imidazolinones are reduced by trichlorosilane in a highly enantioselective fashion when treated with a novel Lewis base organocatalyst that is based on a 2,2′-bispyrrolidine core. Under mild reaction conditions and with low catalyst loading the hydrosilylation reaction provides a broad range of chiral imidazolidinones with various structural motifs including sterically demanding substituents, alkyls and aryls.

ERK INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and a pharmaceutically acceptable carrier. The invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of Formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier.