1,2-di(carboxymethyl)-1-phenylcyclohexane

Base Information

• Chemical Name: 1,2-di(carboxymethyl)-1-phenylcyclohexane
• CAS No.: 117661-01-5
• Molecular Formula: C₁₆H₂₀O₄
• Molecular Weight: 276.332
• Mol file: 117661-01-5.mol

Synonyms:1,2-di(carboxymethyl)-1-phenylcyclohexane

Chemical Property of 1,2-di(carboxymethyl)-1-phenylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-di(carboxymethyl)-1-phenylcyclohexane

There total 2 articles about 1,2-di(carboxymethyl)-1-phenylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(2-oxocyclohexyl)acetate (24731-17-7) → 1,2-di(carboxymethyl)-1-phenylcyclohexane (117661-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / zinc / diethyl ether; benzene / 3 h / Heating

2: 1.) anhydrous aluminium chloride; 2.) potassium hydroxide / 1.) benzene, 5 deg C then rt. overnight; 2.) ethanol, reflux, 4h

With potassium hydroxide; aluminium trichloride; zinc; In diethyl ether; benzene;

DOI:10.1016/S0040-4020(01)85936-6

Reference yield:

7a-carbethoxymethyloctahydrobenzofuran-2-one (107153-71-9) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1,2-di(carboxymethyl)-1-phenylcyclohexane (117661-01-5)

Guidance literature:

With potassium hydroxide; aluminium trichloride; Yield given. Multistep reaction; 1.) benzene, 5 deg C then rt. overnight; 2.) ethanol, reflux, 4h;

DOI:10.1016/S0040-4020(01)85936-6

Reference yield: 74.0%

1,2-di(carboxymethyl)-1-phenylcyclohexane (117661-01-5) → 1-phenyl-trans-bicyclo(4.3.0)nonan-8-one (106988-13-0,117661-05-9)

Guidance literature:

With methanol; sodium acetate; In acetic anhydride; for 2.5h; Heating;

DOI:10.1016/S0040-4020(01)85936-6

upstream raw materials:

7a-carbethoxymethyloctahydrobenzofuran-2-one

benzene

ethyl 2-(2-oxocyclohexyl)acetate

Downstream raw materials:

1-phenyl-trans-bicyclo(4.3.0)nonan-8-one

1-phenylbicyclo<4,3,0>non-6-en-8-one

(3aS,7aS)-1-Bromo-3a-phenyl-octahydro-inden-2-one

(3aS,7aR)-3a-Phenyl-octahydro-inden-2-one oxime