3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one

Base Information

• Chemical Name: 3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one
• CAS No.: 106988-13-0
• Molecular Formula: C₁₅H₁₈O
• Molecular Weight: 214.307
• Mol file: 106988-13-0.mol

Synonyms:

Chemical Property of 3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one

There total 4 articles about 3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,2-di(carboxymethyl)-1-phenylcyclohexane (117661-01-5) → 1-phenyl-trans-bicyclo(4.3.0)nonan-8-one (106988-13-0,117661-05-9)

Guidance literature:

With methanol; sodium acetate; In acetic anhydride; for 2.5h; Heating;

DOI:10.1016/S0040-4020(01)85936-6

Reference yield:

selenoanisole (4346-64-9) + 1-phenyl-cis-bicyclo<4.2.0>octan-7-one (39778-70-6) → 3aα-phenyl-1,3,3a,4,5,6,7,7aα-octahydro-2H-inden-2-one (106988-13-0,117661-05-9)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00381a013

Reference yield:

ethyl 2-(2-oxocyclohexyl)acetate (24731-17-7) → 1-phenyl-trans-bicyclo(4.3.0)nonan-8-one (106988-13-0,117661-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / zinc / diethyl ether; benzene / 3 h / Heating

2: 1.) anhydrous aluminium chloride; 2.) potassium hydroxide / 1.) benzene, 5 deg C then rt. overnight; 2.) ethanol, reflux, 4h

3: 74 percent / sodium acetate, methanol / acetic anhydride / 2.5 h / Heating

With methanol; potassium hydroxide; aluminium trichloride; sodium acetate; zinc; In diethyl ether; acetic anhydride; benzene;

DOI:10.1016/S0040-4020(01)85936-6

upstream raw materials:

1,2-di(carboxymethyl)-1-phenylcyclohexane

ethyl 2-(2-oxocyclohexyl)acetate

7a-carbethoxymethyloctahydrobenzofuran-2-one

selenoanisole

Downstream raw materials:

(3aS,7aS)-1-Bromo-3a-phenyl-octahydro-inden-2-one

(3aS,7aR)-3a-Phenyl-octahydro-inden-2-one oxime

7-oximino-1-phenyl-trans-bicyclo<4.3.0>nonan-8-one

1-phenylbicyclo<4,3,0>non-6-en-8-one