Technology Process of 4-butoxy-3-ethoxy-5-(5-nitropyridin-2-yl)benzaldehyde
There total 5 articles about 4-butoxy-3-ethoxy-5-(5-nitropyridin-2-yl)benzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate;
In
Dimethyl ether; water;
for 2h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
1.2: 2 h / -10 °C
2.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; sodium carbonate;
In
tetrahydrofuran; Dimethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C
2.1: ammonium chloride / ethanol / 4 h / Reflux
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
3.2: 2 h / -10 °C
4.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; sodium carbonate; potassium carbonate; ammonium chloride;
In
tetrahydrofuran; ethanol; Dimethyl ether; N,N-dimethyl acetamide; water;