Technology Process of 3-(5-aminopyridin-2-yl)-4-butoxy-5-ethoxybenzaldehyde
There total 6 articles about 3-(5-aminopyridin-2-yl)-4-butoxy-5-ethoxybenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
iron; ammonium chloride;
In
ethanol;
at 75 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
1.2: 2 h / -10 °C
2.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
3.1: iron; ammonium chloride / ethanol / 1 h / 75 °C
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; iron; sodium carbonate; ammonium chloride;
In
tetrahydrofuran; ethanol; Dimethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl acetamide / 4 h / 60 °C
2.1: ammonium chloride / ethanol / 4 h / Reflux
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C
3.2: 2 h / -10 °C
4.1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; Dimethyl ether / 2 h / Inert atmosphere; Reflux
5.1: iron; ammonium chloride / ethanol / 1 h / 75 °C
With
bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); isopropylmagnesium chloride; iron; sodium carbonate; potassium carbonate; ammonium chloride;
In
tetrahydrofuran; ethanol; Dimethyl ether; N,N-dimethyl acetamide; water;
