(R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol

Base Information

• Chemical Name: (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol
• CAS No.: 1256467-62-5
• Molecular Formula: C₃₇H₄₃NO₅
• Molecular Weight: 581.752

Synonyms:(R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol

Chemical Property of (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol

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Technology Process of (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol

There total 1 articles about (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C39H43NO6 (1256467-80-7) → (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol (1256467-62-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol102266j

Reference yield: 93.0%

(R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol (1256467-62-5) + acetic anhydride (108-24-7) → (R,E)-4-(((1R,2S)-2-acetoxy-1-(4-methoxyphenyl)-3-phenylpropyl)((S)-1,1-dimethoxy-3-phenylpropan-2-yl)amino)-1-phenylbut-2-enyl acetate (1256467-85-2)

Guidance literature:

With pyridine; dmap; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol102266j

Reference yield: 82.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + (R,E)-4-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-1-phenylbut-2-en-1-ol (1256467-62-5) → (S,E)-3-((((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)methyl)-N,N-dimethyl-5-phenylpent-4-enamide (1256467-64-7)

Guidance literature:

In toluene; at 100 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/ol102266j

upstream raw materials:

C₃₉H₄₃NO₆

Downstream raw materials:

(S,E)-3-((((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)methyl)-N,N-dimethyl-5-phenylpent-4-enamide

(R,E)-4-(((1R,2S)-2-acetoxy-1-(4-methoxyphenyl)-3-phenylpropyl)((S)-1,1-dimethoxy-3-phenylpropan-2-yl)amino)-1-phenylbut-2-enyl acetate

2,2,2-trichloro-N-((S,E)-1-(((S)-1,1-dimethoxy-3-phenylpropan-2-yl)((1R,2S)-2-hydroxy-1-(4-methoxyphenyl)-3-phenylpropyl)amino)-4-phenylbut-3-en-2-yl)acetamide

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