dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

Base Information

Chemical Name:dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine
CAS No.:496955-62-5
Molecular Formula:C₂₅H₂₆N₈
Molecular Weight:438.535
Hs Code.:

Synonyms:dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

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Chemical Property of dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

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Technology Process of dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

There total 7 articles about dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496955-47-6
dibenzyl-(2-chloro-9H-purin-6-yl)amine

: 496955-62-5
dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

2.1: 63 percent / Pd(PPh₃)4 / 1-methyl-pyrrolidin-2-one / 8 h / 120 °C

3.1: 100 percent / H₂ / Pd/C / ethanol / 20 °C / 3040 Torr

4.1: 100 percent / Br₂ / methanol; tetrahydrofuran; acetate buffer / 12 h / 20 °C / pH 4

5.1: NaH / dimethylformamide / 1 h

5.2: dimethylformamide / 12 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetate buffer; N,N-dimethyl-formamide; 2.1: Stille reaction;
DOI:10.1021/jm058018d

Reference yield:

: 496955-48-7
dibenzyl-(2-chloro-9-methyl-9H-purin-6-yl)amine

: 496955-62-5
dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 63 percent / Pd(PPh₃)4 / 1-methyl-pyrrolidin-2-one / 8 h / 120 °C

2.1: 100 percent / H₂ / Pd/C / ethanol / 20 °C / 3040 Torr

3.1: 100 percent / Br₂ / methanol; tetrahydrofuran; acetate buffer / 12 h / 20 °C / pH 4

4.1: NaH / dimethylformamide / 1 h

4.2: dimethylformamide / 12 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetate buffer; N,N-dimethyl-formamide; 1.1: Stille reaction;
DOI:10.1021/jm058018d

Reference yield:

: 496955-49-8
dibenzyl-(2-isopropenyl-9-methyl-9H-purin-6-yl)amine

: 496955-62-5
dibenzyl-(2-isopropyl-9-methyl-8-([1,2,3]triazol-2-yl)-9H-purin-6-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂ / Pd/C / ethanol / 20 °C / 3040 Torr

2.1: 100 percent / Br₂ / methanol; tetrahydrofuran; acetate buffer / 12 h / 20 °C / pH 4

3.1: NaH / dimethylformamide / 1 h

3.2: dimethylformamide / 12 h / 100 °C

With hydrogen; bromine; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetate buffer; N,N-dimethyl-formamide;
DOI:10.1021/jm058018d