[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

Base Information

Chemical Name:[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester
CAS No.:439296-20-5
Molecular Formula:C₂₃H₂₆N₂O₄
Molecular Weight:394.47
Hs Code.:

Synonyms:[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

There total 13 articles about [(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 439296-17-0
(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

: 439296-20-5
[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: With triethylamine; In toluene; for 7h; Heating;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 439296-20-5
[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / (DHQD)2-PHAL; CH₃SO₂NH₂; K₂CO₃ / K₃Fe(CN)6; OsO₄ / 2-methyl-propan-2-ol; H₂O / 11 h / 0 °C

2: 81 percent / Raney Ni / ethanol / 3 h / Heating

3: Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

4: NaN₃ / dimethylformamide / 6 h / 60 °C

5: 94 percent / LiOH / methanol / 1 h / 20 °C

6: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

7: Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

8: CH₂Cl₂ / 12 h / 20 °C

9: 56 percent / Et₃N / toluene / 7 h / Heating

With lithium hydroxide; sodium azide; methanesulfonamide; nickel; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; dicyclohexyl-carbodiimide; osmium(VIII) oxide; potassium hexacyanoferrate(III); In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield:

: 20989-19-9,176035-15-7
(2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol

: 439296-20-5
[(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

3: CH₂Cl₂ / 12 h / 20 °C

4: 56 percent / Et₃N / toluene / 7 h / Heating

With benzotriazol-1-ol; Dess-Martin periodane; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1016/S0040-4039(02)00133-8