(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester
CAS No.:439296-17-0
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Suppliers and Price of (E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

There total 12 articles about (E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 439296-17-0
(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / (DHQD)2-PHAL; CH₃SO₂NH₂; K₂CO₃ / K₃Fe(CN)6; OsO₄ / 2-methyl-propan-2-ol; H₂O / 11 h / 0 °C

2: 81 percent / Raney Ni / ethanol / 3 h / Heating

3: Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

4: NaN₃ / dimethylformamide / 6 h / 60 °C

5: 94 percent / LiOH / methanol / 1 h / 20 °C

6: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

7: Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

8: CH₂Cl₂ / 12 h / 20 °C

With lithium hydroxide; sodium azide; methanesulfonamide; nickel; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; dicyclohexyl-carbodiimide; osmium(VIII) oxide; potassium hexacyanoferrate(III); In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield:

: 20989-19-9,176035-15-7
(2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol

: 439296-17-0
(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

3: CH₂Cl₂ / 12 h / 20 °C

With benzotriazol-1-ol; Dess-Martin periodane; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0040-4039(02)00133-8

Reference yield:

: 94790-24-6
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate

: 439296-17-0
(E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / LiCl; NaBH₄ / ethanol; tetrahydrofuran / 4 h

2: 86 percent / 15 percent HCl / ethyl acetate / 1 h / 0 - 20 °C

3: 82 percent / DCC; HOBT / CH₂Cl₂ / 16 h / 0 - 20 °C

4: Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

5: CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; benzotriazol-1-ol; Dess-Martin periodane; dicyclohexyl-carbodiimide; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(02)00133-8