3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

Base Information

Chemical Name:3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide
CAS No.:331466-64-9
Molecular Formula:C₁₉H₁₂F₃N₃OS₂
Molecular Weight:419.451
Hs Code.:

3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-<i>b</i>]pyridine-2-carboxylic acid phenylamide

Synonyms:3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

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Chemical Property of 3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

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Technology Process of 3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

There total 6 articles about 3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 299198-18-8
2-(3-cyano-6-thiophen-2-yl-4-trifluoromethyl-pyridin-2-ylsulfanyl)-N-phenyl-acetamide

: 331466-64-9
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

Guidance literature:: With potassium carbonate; In ethanol; for 3h; Heating;

Reference yield:

: 104960-50-1
C₁₁H₅F₃N₂S₂

: 587-65-5
N-chloroacetyl-aniline

: 331466-64-9
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

Guidance literature:: With potassium carbonate; In ethanol; at 90 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bioorg.2019.103269

Reference yield:

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 331466-64-9
3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NEt₃ / ethanol / 2 h / Heating

2: 80 percent / NaOAc*3H₂O / ethanol / 4 h / Heating

3: 90 percent / K₂CO₃ / ethanol / 3 h / Heating

With sodium acetate; potassium carbonate; triethylamine; In ethanol; 3: Thorpe-Ziegler cyclization;