Technology Process of 4-((difluoromethyl)sulfonyl)benzonitrile
There total 2 articles about 4-((difluoromethyl)sulfonyl)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide / water; acetonitrile / -78 - 20 °C
2: tetrapropylammonium perruthennate; sodium periodate / dichloromethane; acetonitrile / 1 h
3: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.58 h / 140 °C / Sealed tube; Inert atmosphere; Microwave irradiation
With
sodium periodate; tetrakis(triphenylphosphine) palladium(0); tetrapropylammonium perruthennate; potassium hydroxide;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrapropylammonium perruthennate; sodium periodate / dichloromethane; acetonitrile / 1 h
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.58 h / 140 °C / Sealed tube; Inert atmosphere; Microwave irradiation
With
sodium periodate; tetrakis(triphenylphosphine) palladium(0); tetrapropylammonium perruthennate;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
4-((difluoromethyl)sulfonyl)benzonitrile;
With
borane-THF;
In
tetrahydrofuran;
for 2h;
Reflux;
With
methanol;
In
tetrahydrofuran;
at 20 ℃;
