3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

Base Information

Chemical Name:3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide
CAS No.:1321562-54-2
Molecular Formula:C₂₂H₁₆Cl₃F₃N₂O₃
Molecular Weight:519.735
Hs Code.:

Synonyms:3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

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Chemical Property of 3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

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Technology Process of 3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

There total 5 articles about 3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.5%

: 1321562-51-9
3-nitro-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

: 1321562-54-2
3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

Guidance literature:: With sodium dithionite; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h; Reflux;

Reference yield:

: 23516-79-2
4-(trifluoroacetyl)aniline

: 1321562-54-2
3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / acetonitrile / 1.5 h / Reflux

2: tetrahydrofuran / 0 °C / Inert atmosphere

3: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / 1,2-dichloro-ethane / Reflux

4: potassium carbonate / 20 °C

5: sodium hydroxide; sodium dithionite; tetrabutylammomium bromide / water; tetrahydrofuran / 7 h / 20 °C / Reflux

With N-chloro-succinimide; sodium dithionite; tetrabutylammomium bromide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1321562-49-5
1-(4-amino-3,5-dichlorophenyl)-1-(4-chlorophenyl)-2,2,2-trifluoroethanol

: 1321562-54-2
3-amino-N-{2,6-dichloro-4-[1-(4-chlorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]-phenyl}-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / 1,2-dichloro-ethane / Reflux

2: potassium carbonate / 20 °C

3: sodium hydroxide; sodium dithionite; tetrabutylammomium bromide / water; tetrahydrofuran / 7 h / 20 °C / Reflux

With sodium dithionite; tetrabutylammomium bromide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;