Technology Process of 5-[8-(3-cyanophenyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide
There total 5 articles about 5-[8-(3-cyanophenyl)-1,5-naphthyridin-2-yl]-3-pyridinesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
at 120 ℃;
for 0.75h;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / 1,4-dioxane / 20 h / 100 °C / Sealed tube
2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 2 h / 100 °C
4: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.75 h / 120 °C / microwave irradiation
With
hydrogenchloride; water; sodium hydrogencarbonate; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2: water; sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 2 h / 100 °C
3: water; potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.75 h / 120 °C / microwave irradiation
With
water; sodium hydrogencarbonate; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; N,N-dimethyl-formamide;