Technology Process of 1,8,17,24-tetraoxa<8.8>(2,6)-naphthalenophane-3,5,19,21-tetrayne-10,30-dicarboxylic acid dineophyl ester
There total 13 articles about 1,8,17,24-tetraoxa<8.8>(2,6)-naphthalenophane-3,5,19,21-tetrayne-10,30-dicarboxylic acid dineophyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper diacetate;
In
pyridine;
at 42 ℃;
for 2h;
DOI:10.1021/ja00389a050
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 52 percent / NaHCO3 / dimethylformamide / 1 h / 70 °C
2: 80 percent / K2CO3 / acetone / 11 h / Heating
3: 1.) n-BuLi, 2.) KOH / 1.) 0 deg C, 1 h; room temperature, overnight, 2.) MeOH, reflux, 4 h
4: 99 percent / 4-(dimethylamino)pyridine, cyclohexyl carbodiimide / CH2Cl2 / 3 h / Ambient temperature
5: 93 percent / HCl gas / benzene / 0.07 h
6: 87 percent / cupric acetate monohydrate / pyridine / 2.5 h / 40 °C
7: 66 percent / K2CO3 / acetone / 45 h / Heating
8: cupric acetate monohydrate / pyridine / 2 h / 42 °C
With
hydrogenchloride; dmap; potassium hydroxide; n-butyllithium; N-cyclohexylcarbodiimide; copper diacetate; sodium hydrogencarbonate; potassium carbonate;
In
pyridine; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ja00389a050
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 81 percent / KOH / 1.5 h / 250 - 300 °C
2: 52 percent / NaHCO3 / dimethylformamide / 1 h / 70 °C
3: 80 percent / K2CO3 / acetone / 11 h / Heating
4: 1.) n-BuLi, 2.) KOH / 1.) 0 deg C, 1 h; room temperature, overnight, 2.) MeOH, reflux, 4 h
5: 99 percent / 4-(dimethylamino)pyridine, cyclohexyl carbodiimide / CH2Cl2 / 3 h / Ambient temperature
6: 93 percent / HCl gas / benzene / 0.07 h
7: 87 percent / cupric acetate monohydrate / pyridine / 2.5 h / 40 °C
8: 66 percent / K2CO3 / acetone / 45 h / Heating
9: cupric acetate monohydrate / pyridine / 2 h / 42 °C
With
hydrogenchloride; dmap; potassium hydroxide; n-butyllithium; N-cyclohexylcarbodiimide; copper diacetate; sodium hydrogencarbonate; potassium carbonate;
In
pyridine; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ja00389a050
