83511-07-3

Basic information

• Product Name: 3,7-Dihydroxy-2-naphthoic acid
• Synonyms: 2,6-DIOXYNAPHTHALENE-3-CARBOXYLIC ACID;3,7-DIHYDROXY-2-NAPHTHALENECARBOXYLIC ACID;3,7-DIHYDROXY-2-NAPHTHOIC ACID;3,7-Dihydroxy-2-naphtoic acid;2,6-Dihydroxy-3-naphthalenecarboxylic acid;3,7-DIHYDROXY-2-NAPHTHOIC ACID 95%;2,6-Dihydroxy-3-Naphthoic acid (3,7-Dihydroxy-2-naphthoic acid);3,7-DIHYDROXY-2-NAPHTHOIC ACID 90+%
• CAS NO: 83511-07-3
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.18
• Product Categories: C11 to C12;Carbonyl Compounds;Carboxylic Acids;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Naphthalene series
• Mol File: 83511-07-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 265 °C±10 °C (dec.)(lit.)
• Boiling Point: 442.2 °C at 760 mmHg
• Flash Point: 235.3 °C
• Appearance: Yellow powder or beige crystalline.
• Density: 1.535 g/cm³
• Vapor Pressure: 1.35E-08mmHg at 25°C
• Refractive Index: 1.761
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 3288005
• CAS DataBase Reference: 3,7-Dihydroxy-2-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-Dihydroxy-2-naphthoic acid(83511-07-3)
• EPA Substance Registry System: 3,7-Dihydroxy-2-naphthoic acid(83511-07-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-38
• Safety Statements: 26
• WGK Germany: 3
• F: 9
• Hazardous Substances Data: 83511-07-3(Hazardous Substances Data)

Usage

Uses

3,7-Dihydroxy-2-naphthoic acid was used in the synthesis of 3-hydroxy-7-methoxy-2-naphthoic acid.

General Description

3,7-Dihydroxy-2-naphthoic acid served as a substrate for the enzyme NcsB1 (an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin) in the NcsB1-catalyzed O-methylation of 2,7-dihydroxy-5-methyl-1-naphthoic acid.

InChI:InChI=1/C11H8O4/c12-8-2-1-6-5-10(13)9(11(14)15)4-7(6)3-8/h1-5,12-13H,(H,14,15)

Upstream product

• 861335-47-9 7-amino-3-methoxy-[2]naphthoic acid 
• 883-62-5 3-methoxy-2-naphthoic acid 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 856210-23-6 3-hydroxy-4,7-disulfo-[2]naphthoic acid 
• 7664-93-9 sulfuric acid 
• 64863-13-4 7-amino-3-hydroxy-[2]naphthoic acid 
• 15509-36-1 3-hydroxy-7-sulfo-[2]naphthoic acid 
• 26513-28-0 sodium 2-carboxy-3-hydroxy-7-naphthalenesulfonate 
• 858020-91-4 2-hydroxy-3-phenylcarbamoyl-naphthalene-1,6-disulfonic acid 

Downstream Products

• 143355-56-0 3-hydroxy-7-methoxynaphthalene-2-carboxylic acid 

Relevant articles and documents

Biocatalytic synthesis of dihydroxynaphthoic acids by cytochrome P450 CYP199A2

CYP199A2, a bacterial P450 monooxygenase from Rhodopseudomonas palustris, was found to exhibit oxidation activity towards three hydroxynaphthoic acids. Whole cells of the recombinant Escherichia coli strain expressing CYP199A2 efficiently catalyzed the re

1,8,17,24-Tetraoxa(2,6)naphthalenophane-3,5,19,21-tetrayne-10,13-dicarboxylic Acid Derivatives, Novel Complexors of Aromatic Guests

Synthesis and complexation behavior of the title molecules are described.Study of aromatic solvent induced shifts of these molecules support the contention that their large cavity can accomodate aromatic rings.The behavior of acid 1a in water suggests that this effect enhanced in aqueous medium, as is expected for formation of hydrophobic inclusion complexes.In contrast to the rigid naphthalenophanes (1), their saturated derivatives (7) exist in a collapsed conformation and do not incorporate aromatic guests.