Chemical Property of Elemicin
Chemical Property:
- Appearance/Colour:Colorless oil-like liquid
- Vapor Pressure:0.00666mmHg at 25°C
- Refractive Index:1.496
- Boiling Point:279.8 °C at 760 mmHg
- Flash Point:92.6 °C
- PSA：27.69000
- Density:1.011 g/cm3
- LogP:2.44090
- Storage Temp.:Amber Vial, -20°C Freezer
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
- XLogP3:2.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:5
- Exact Mass:208.109944368
- Heavy Atom Count:15
- Complexity:179
- Purity/Quality:
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99%, *data from raw suppliers
Elemicin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC=C
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Description
Elemicin is a trioxygenated phenylpropane that has been found in A. dracunculus. It is active against S. aureus, B. subtilis, and C. albicans (MICs = 600, 2,500, and 1,000 mg/L, respectively) but not E. coli, K. pneumoniae, P. aeruginosa (MICs = >8,000 mg/L for all), or L. monocytogenes (MIC = >3,000 mg/L). Elemicin is toxic to mice following metabolic activation to 1’-hydroxyelemicin by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. It increases plasma and hepatic triglyceride levels, decreases stearoyl-CoA desaturase 1 (Scd1) expression, and induces hepatomegaly in mice when administered at a dose of 500 mg/kg per day for three weeks.
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Uses
A constituent of the essential oil of nutmeg and is responsible for the psychoactive effects of nutmeg. Also a minor constituent of the oleoresin and essential oil of Manila elemi (Canarium luzonicum). Exhibits anticholinergic-like effects in humans.
