(+)-(S)-2-Phenyl-2-methoxyethyl bromide

Base Information

• Chemical Name: (+)-(S)-2-Phenyl-2-methoxyethyl bromide
• CAS No.: 22810-55-5
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.09
• Mol file: 22810-55-5.mol

Synonyms:(+)-(S)-2-Phenyl-2-methoxyethyl bromide

Chemical Property of (+)-(S)-2-Phenyl-2-methoxyethyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S)-2-Phenyl-2-methoxyethyl bromide

There total 7 articles about (+)-(S)-2-Phenyl-2-methoxyethyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-2-methoxy-2-phenyl-1-ethylmethanesulfonate (269401-67-4) → (+)-(S)-2-Phenyl-2-methoxyethyl bromide (22810-55-5)

Guidance literature:

With lithium bromide; In acetone; for 20h; Heating;

DOI:10.1016/S0968-0896(00)00121-8

Reference yield:

(S)-2-methoxy-2-phenylethylene para-toluenesulphonate (61825-54-5) → (+)-(S)-2-Phenyl-2-methoxyethyl bromide (22810-55-5)

Guidance literature:

With lithium bromide; In dimethyl sulfoxide; at 60 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201800777

Reference yield:

(S)-Mandelic acid (17199-29-0) → (+)-(S)-2-Phenyl-2-methoxyethyl bromide (22810-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 30 percent / NaOH / H₂O / 1 h / 50 °C

2: 82 percent / BH₃ / tetrahydrofuran / 0 - 20 °C

3: 1.33 g / Et₃N / CH₂Cl₂ / 0 - 20 °C

4: 81 percent / LiBr / acetone / 20 h / Heating

With sodium hydroxide; borane; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane; water; acetone; 1: Methylation / 2: Reduction / 3: mesylation / 4: Substitution;

DOI:10.1016/S0968-0896(00)00121-8

upstream raw materials:

(S)-2-methoxy-2-phenyl-1-ethylmethanesulfonate

(S)-Mandelic acid

(S)-2-methoxy-2-phenylacetic acid

(S)-2-methoxy-2-phenylethanol

Downstream raw materials:

(+)-Neomenthyl 2-phenyl-2-methoxyethyl sulfide

(S)-2-methoxy-2-phenyl-ethylmethanethiosulfonate