(S)-(+)-2-METHOXY-2-PHENYLETHANOL

Base Information

• Chemical Name: (S)-(+)-2-METHOXY-2-PHENYLETHANOL
• CAS No.: 66051-01-2
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol file: 66051-01-2.mol

Synonyms:(S)-(+)-2-METHOXY-2-PHENYLETHANOL;(+)-BETA-METHOXYPHENETHYL ALCOHOL;BETA-METHOXYPHENETHYL ALCOHOL;(S)-(+)-beta-Methoxyphenethyl alcohol;(s)-(+)-á-methoxyphenethyl alcohol;(S)-(+)-2-Methoxy-2-phenylethanol, 98+%;β-Methoxyphenethyl alcohol, (+)-β-Methoxyphenethyl alcohol;(S)-(+)-2-Methoxy-2-phenylethanol 98%

Chemical Property of (S)-(+)-2-METHOXY-2-PHENYLETHANOL

Chemical Property:

• Vapor Pressure: 0.0212mmHg at 25°C
• Refractive Index: n20/D 1.52(lit.)
• Boiling Point: 65 °C0.1 mm Hg(lit.)
• PKA: 14.18±0.10(Predicted)
• Flash Point: 208 °F
• PSA: 29.46000
• Density: 1.054 g/mL at 25 °C(lit.)
• LogP: 1.36640

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-(+)-2-Methoxy-2-phenylethanol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-(+)-2-Methoxy-2-phenylethanol can be used:As a starting material for the synthesis of N-substituted?6,7-benzomorphan based opioid receptor agonists.As a ligand in the preparation of organolanthanoid complexes.As starting material for the synthesis of N-acetyl-O-((2S)-2-methoxy-2-phenylethyl)-L-serine, a serine proteases inhibitor.

Technology Process of (S)-(+)-2-METHOXY-2-PHENYLETHANOL

There total 30 articles about (S)-(+)-2-METHOXY-2-PHENYLETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-(tert-butyldimethylsilyloxy)-1-methoxy-1-phenylethane (192987-77-2) → (S)-2-methoxy-2-phenylethanol (66051-01-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/S0957-4166(03)00023-5

Reference yield: 98.9%

(S)-2-methoxy-2-phenylacetic acid (26164-26-1) → (S)-2-methoxy-2-phenylethanol (66051-01-2)

Guidance literature:

With sulfuric acid; In diethyl ether; water;

Reference yield: 92.0%

(S)-methyl 2-methoxy-2-phenylacetate (3558-61-0,32174-46-2,56143-21-6,26164-27-2) → (S)-2-methoxy-2-phenylethanol (66051-01-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201800777

upstream raw materials:

methanol

(R)-Styrene oxide

(S)-2-methoxy-2-phenylacetic acid

C₂₃H₂₄OS₂

Downstream raw materials:

(S)-(+)-2-methoxy-2-phenylethyl acetoacetate

(-)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine

(+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine

(S)-2-methoxy-2-phenylethylene para-toluenesulphonate