2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

Base Information

Chemical Name:2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile
CAS No.:1293956-55-4
Molecular Formula:C₂₂H₁₂Cl₂N₆S₄
Molecular Weight:559.547
Hs Code.:

Synonyms:2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

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Chemical Property of 2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

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Technology Process of 2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

There total 3 articles about 2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5-(4-chlorophenyl)-2-(chloromethyl)-1,3,4-thiadiazole

: 75-15-0,12122-00-8
carbon disulfide

: 109-77-3
malononitrile

: 1293956-55-4
2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

Guidance literature:: carbon disulfide; malononitrile; With sodium ethanolate; at 0 ℃; for 1h;

5-(4-chlorophenyl)-2-(chloromethyl)-1,3,4-thiadiazole; In ethanol; at 20 - 30 ℃;
DOI:10.1016/j.ejmech.2011.01.063

Reference yield:

: 24068-15-3
2‐(chloromethyl)‐5‐(4‐chlorophenyl)‐1,3,4‐oxadiazole

: 1293956-55-4
2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: thiourea / tetrahydrofuran / 120 - 150 °C / Sealed tube

2.1: sodium ethanolate / 1 h / 0 °C

2.2: 20 - 30 °C

With sodium ethanolate; thiourea; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.01.063

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1293956-55-4
2-(bis((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)methylthio)methylene)malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / Reflux

2.1: thiourea / tetrahydrofuran / 120 - 150 °C / Sealed tube

3.1: sodium ethanolate / 1 h / 0 °C

3.2: 20 - 30 °C

With sodium ethanolate; thiourea; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.01.063