Technology Process of C14H15F2N3O2*ClH
There total 14 articles about C14H15F2N3O2*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tert-butyl methyl ether; acetone;
at 0 - 40 ℃;
for 3h;
- Guidance literature:
-
In
4-methyl-2-pentanone; butan-1-ol;
at 60 ℃;
for 4h;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: magnesium; Chloromethyltrimethylsilane / tert-butyl methyl ether / 4 h / 55 °C
1.2: -10 - 0 °C
1.3: 3 h / 25 - 50 °C
2.1: sodium hydroxide / dimethyl sulfoxide / 3 h / 25 - 30 °C
3.1: lithium chloride; sodium tetrahydroborate / isopropyl alcohol; water / 20 h / -5 - 30 °C
3.2: pH 1
4.1: sodium hydrogencarbonate / Novo SP 435 (Candida antartica, Novozym 435) / toluene / 24 h / -15 °C / Enzymatic reaction
5.1: sodium hydrogencarbonate; iodine / ethyl acetate / 5 h / -15 °C
6.1: dimethyl sulfoxide / 24 h / 85 - 90 °C
6.2: 3 h / 25 - 30 °C
7.1: hydrogenchloride / tert-butyl methyl ether; acetone / 3 h / 0 - 40 °C
With
hydrogenchloride; sodium tetrahydroborate; iodine; sodium hydrogencarbonate; magnesium; lithium chloride; sodium hydroxide; Chloromethyltrimethylsilane;
Novo SP 435 (Candida antartica, Novozym 435);
In
tert-butyl methyl ether; water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; toluene;
![[(R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-methanol](/Databaselist/images/loading.webp)
