Technology Process of 2-<2-(O-methylephedrinyl)-1-naphthyl>oxazoline
There total 5 articles about 2-<2-(O-methylephedrinyl)-1-naphthyl>oxazoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Et3N / 1,2-dichloro-ethane
2: thionyl chloride / CH2Cl2; benzene / 4 h / Ambient temperature
3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, 2 h
With
n-butyllithium; thionyl chloride; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja00029a032
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 1 h, 2.) THF, pentane, from -78 deg C to RT, 1 h
2: oxalyl chloride / CH2Cl2 / 5 h
3: Et3N / 1,2-dichloro-ethane
4: thionyl chloride / CH2Cl2; benzene / 4 h / Ambient temperature
5: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, 2 h
With
n-butyllithium; thionyl chloride; oxalyl dichloride; tert.-butyl lithium; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja00029a032
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl chloride / CH2Cl2 / 5 h
2: Et3N / 1,2-dichloro-ethane
3: thionyl chloride / CH2Cl2; benzene / 4 h / Ambient temperature
4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 0.5 h, 2.) THF, hexane, 2 h
With
n-butyllithium; thionyl chloride; oxalyl dichloride; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja00029a032