1-(PHENYLETHYNYL)-1-CYCLOHEXANOL

Base Information

• Chemical Name: 1-(PHENYLETHYNYL)-1-CYCLOHEXANOL
• CAS No.: 20109-09-5
• Molecular Formula: C14H16 O
• Molecular Weight: 200.28
• Hs Code.: 2906299090
• Mol file: 20109-09-5.mol

Synonyms:Cyclohexanol,1-(phenylethynyl)- (6CI,7CI,8CI,9CI);1-(1-Hydroxycyclohexyl)-2-phenylacetylene; 1-(Phenylethynyl)-1-cyclohexanol;1-(Phenylethynyl)cyclohexanol; 1-Hydroxy-1-(phenylethynyl)cyclohexane

Chemical Property of 1-(PHENYLETHYNYL)-1-CYCLOHEXANOL

Chemical Property:

• Vapor Pressure: 4.02E-05mmHg at 25°C
• Melting Point: 60-62°C
• Boiling Point: 337.7°Cat760mmHg
• Flash Point: 155.8°C
• PSA: 20.23000
• Density: 1.08g/cm³
• LogP: 2.73330

Purity/Quality:

97% ^*data from raw suppliers

1-(PHENYLETHYNYL)CYCLOHEXANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(PHENYLETHYNYL)-1-CYCLOHEXANOL

There total 24 articles about 1-(PHENYLETHYNYL)-1-CYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + phenylacetylene (536-74-3) → 1-(phenylethynyl)-1-cyclohexanol (20109-09-5)

Guidance literature:

phenylacetylene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

cyclohexanone; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;

DOI:10.1021/ol070224n

Reference yield: 99.0%

iodobenzene (591-50-4) + 1-Ethynylcyclohexan-1-ol (78-27-3) → 1-(phenylethynyl)-1-cyclohexanol (20109-09-5)

Guidance literature:

With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; at 80 ℃;

DOI:10.1016/j.tet.2007.10.031

Reference yield: 94.0%

1-iodo-2-phenylethyne (932-88-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(phenylethynyl)-1-cyclohexanol (20109-09-5)

Guidance literature:

With indium; In dichloromethane; for 0.4h; Heating;

DOI:10.1016/S0040-4039(02)01052-3

upstream raw materials:

phenylethynylmagnesium bromide

cyclohexanone

phenylacetylene

benzene

Downstream raw materials:

cyclohex-1-enylethynylbenzene

2-cyclohexylidene-1-phenyl-1-ethanone

(E)-1-(2-phenyl-1-ethenyl)cyclohexanol

((1-methoxycyclohexyl)ethynyl)benzene