1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

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Chemical Name:1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea
CAS No.:1282613-20-0
Molecular Formula:C₁₉H₁₈ClN₅O₂S
Molecular Weight:415.903
Hs Code.:

Synonyms:1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

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Chemical Property of 1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

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Technology Process of 1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

There total 7 articles about 1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 6298-19-7
2-chloro-3-aminopyridine

: 1220708-87-1
4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)benzaldehyde

: 1282613-20-0
1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: 4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)benzaldehyde; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

With bis(trichloromethyl) carbonate; In tetrahydrofuran; for 0.25h;

2-chloro-3-aminopyridine; In tetrahydrofuran; at 20 ℃;

Reference yield: 47.0%

: 6298-19-7
2-chloro-3-aminopyridine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1220708-87-1
4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)benzaldehyde

: 1282613-20-0
1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: 4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)benzaldehyde; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

2-chloro-3-aminopyridine; bis(trichloromethyl) carbonate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 592-82-5
butyl isothiocyanate

: 1282613-20-0
1-butyl-3-(2-chloropyridin-3-yl)-1-(5-(4-formylphenyl)-1,3,4-thiadiazol-2-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / methanol / 10 - 15 °C

2.1: trichlorophosphate / 1,4-dioxane / 0.5 h / 20 °C

2.2: 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 - 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

5.2: 0.25 h

5.3: 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydrazine hydrate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;