(E)-2-(4-methylstyryl)-1H-indole

Base Information

• Chemical Name: (E)-2-(4-methylstyryl)-1H-indole
• CAS No.: 1429508-94-0
• Molecular Formula: C₁₇H₁₅N
• Molecular Weight: 233.313
• Mol file: 1429508-94-0.mol

Synonyms:(E)-2-(4-methylstyryl)-1H-indole

Chemical Property of (E)-2-(4-methylstyryl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4-methylstyryl)-1H-indole

There total 2 articles about (E)-2-(4-methylstyryl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-ethyl 2-(4-methylstyryl)-1H-indole-1-carboxylate (880263-74-1) → (E)-2-(4-methylstyryl)-1H-indole (1429508-94-0)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41514g

Reference yield: 58.0%

1H-indol-2-ylcarboxaldehyde (19005-93-7) + 4-methylbenzyltriphenylphosphonium bromide (2378-86-1) → (E)-2-(4-methylstyryl)-1H-indole (1429508-94-0)

Guidance literature:

4-methylbenzyltriphenylphosphonium bromide; With sodium hydride; In toluene; mineral oil; at 0 - 20 ℃; for 0.75h; Schlenk technique; Inert atmosphere;

1H-indol-2-ylcarboxaldehyde; In toluene; mineral oil; at 80 ℃; for 2h;

DOI:10.1002/adsc.201700092

Reference yield: 93.0%

(E)-2-(4-methylstyryl)-1H-indole (1429508-94-0) + methyl iodide (74-88-4) → (E)-1-methyl-2-(4-methylstyryl)-1H-indole (1192578-66-7)

Guidance literature:

(E)-2-(4-methylstyryl)-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41514g

upstream raw materials:

(E)-ethyl 2-(4-methylstyryl)-1H-indole-1-carboxylate

1H-indol-2-ylcarboxaldehyde

4-methylbenzyltriphenylphosphonium bromide

Downstream raw materials:

3-((E)-3-(1-methyl-2-((E)-4-methylstyryl)-1H-indol-3-yl)prop-1-en-1-yl)oxazolidin-2-one

3-((E)-3-(2-((E)-4-methylstyryl)-1H-indol-3-yl)prop-1-en-1-yl)oxazolidin-2-one

(E)-1-methyl-2-(4-methylstyryl)-1H-indole