Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)-

Base Information

Chemical Name:Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)-
CAS No.:127263-13-2
Molecular Formula:C27H29 N O3
Molecular Weight:415.52
Hs Code.:
DSSTox Substance ID:DTXSID80861292
Nikkaji Number:J3.113.292D
ChEMBL ID:CHEMBL1568239
Mol file:127263-13-2.mol

Synonyms:(3-diphenylmethoxy-1-(3,4)-methylenedioxyphenethyl)piperidine;zamifenacin;zamifenacin, (R)-isomer

Suppliers and Price of Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)-

Chemical Property:

Vapor Pressure:2.04E-11mmHg at 25°C
Boiling Point:532.5°Cat760mmHg
Flash Point:145.6°C
PSA：30.93000
Density:1.2g/cm³
LogP:5.16630
XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:415.21474379
Heavy Atom Count:31
Complexity:513

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)CCC2=CC3=C(C=C2)OCO3)OC(C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)-

There total 7 articles about Piperidine, 1-(2-(1,3-benzodioxol-5-yl)ethyl)-3-(diphenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-hydroxypiperidin-2-one

: 90-99-3
diphenylchloromethane

: 127263-13-2
3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine

Guidance literature:: 1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-hydroxypiperidin-2-one; With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

diphenylchloromethane; With silver carbonate; at 100 ℃; for 2h;
DOI:10.1021/acs.orglett.9b04432

Reference yield: 10.0%

: 1086136-00-6
1-(2-benzo[1,3]dioxol-5-yl-ethyl)-piperidin-3-ol

: 90-99-3
diphenylchloromethane

: 127263-13-2
3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine

Guidance literature:: In dimethyl sulfoxide; at 110 ℃; for 12h;

Reference yield:

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 127263-13-2
3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 56 °C

3: dimethyl sulfoxide / 12 h / 110 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;