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90-99-3

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90-99-3 Usage

Description

Chlorodiphenylmethane is a clear colorless to yellow liquid that serves as a versatile chemical intermediate and initiator in various chemical reactions and synthesis processes.

Uses

Used in Controlled Radical Polymerization:
Chlorodiphenylmethane is used as an initiator in the controlled radical polymerization of styrene, catalyzed by ionic iron complexes. Its role as an initiator allows for the controlled growth of polymer chains, resulting in polymers with specific properties and applications.
Used in Pharmaceutical Industry:
Chlorodiphenylmethane is used as a pharmaceutical intermediate, specifically in the synthesis of diphenhydramine, a widely used antihistamine drug. Its intermediate role enables the production of essential medications for treating various allergic conditions.
Used in Synthesis of Trimethylhydroquinone Derivatives:
Chlorodiphenylmethane also serves as a starting reagent in the synthesis of trimethylhydroquinone derivatives, which are important compounds with potential applications in various industries, including pharmaceuticals and materials science.

Preparation

Chlorodiphenylmethane was synthesized by the radical substitution reaction between diphenylmethane and chlorine gas.

Purification Methods

Diphenylmethyl chloride (benzhydryl chloride) [90-99-3] M 202.7, m 17.0o, b 140o/3mm, 1 6 7o/17mm, n 1.5960. Dry the chloride with Na2SO4 and fractionally distil it under reduced pressure. [Beilstein 5 H 590, 5 I 278, 5 II 500, 5 III 1790, 5 IV 1847.]

Check Digit Verification of cas no

The CAS Registry Mumber 90-99-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90-99:
(4*9)+(3*0)+(2*9)+(1*9)=63
63 % 10 = 3
So 90-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H11Cl/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H

90-99-3 Well-known Company Product Price

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  • Alfa Aesar

  • (B24764)  Benzhydryl chloride, 98%   

  • 90-99-3

  • 25g

  • 430.0CNY

  • Detail
  • Alfa Aesar

  • (B24764)  Benzhydryl chloride, 98%   

  • 90-99-3

  • 100g

  • 1362.0CNY

  • Detail
  • Alfa Aesar

  • (B24764)  Benzhydryl chloride, 98%   

  • 90-99-3

  • 500g

  • 5452.0CNY

  • Detail

90-99-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Chlorodiphenylmethane

1.2 Other means of identification

Product number -
Other names DIPHENYLCHLOROMETHANE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:90-99-3 SDS

90-99-3Relevant articles and documents

Metal-free iodine-promoted direct synthesis of unsymmetrical triarylmethanes

Gu, Ying-Chun,Huang, Jie,Wu, Run-Shi,Xu, Da-Zhen,Yang, Qi,Yu, Ya-Qin

, p. 5519 - 5525 (2020/04/17)

A highly efficient strategy to synthesize completely unsymmetrical triarylmethanes promoted by iodine under metal-free conditions has been successfully developed. Three different aryl groups were introduced into triarylmethanes in a one-pot reaction from inexpensive and readily available salicylaldehydes, arylboronic acids and arenes via o-QM intermediates generated in situ, delivering a wide range of unsymmetrical triarylmethanes bearing various functional groups in good yields with excellent chemoselectivity.

Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system

Xing, Bing-Han,Zhao, Xuan-Xuan,Qin, Yu-Jun,Zhang, Pu,Guo, Zhi-Xin

, p. 667 - 675 (2020/05/22)

Deoxygenative chlorination of carbonyl compounds using the HMe2SiCl/FeCl3/EtOAc and HMeSiCl2/FeCl3/EtOAc systems has been systemically investigated. The HMe2SiCl-FeCl3 system showed the advantages of good substrate applicability, mild reaction conditions, simple operation, low cost, and easy availability of raw materials. Also, it provided a simple and efficient synthesis route for carbonyl deoxychlorination via a one-pot method. Using the HMeSiCl2/FeCl3/EtOAc system, the β-methylchalcone derivative could be obtained in good yields in addition to obtaining the chlorinated compound. Finally, two plausible reaction routes were proposed to describe the formation of the chlorinated compound and the β-methylchalcone derivative.

Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment

Alapafuja, Shakiru O.,Malamas, Michael S.,Shukla, Vidyanand,Zvonok, Alexander,Miller, Sally,Daily, Laura,Rajarshi, Girija,Miyabe, Christina Yume,Chandrashekhar, Honrao,Wood, JodiAnne,Tyukhtenko, Sergiy,Straiker, Alex,Makriyannis, Alexandros

, p. 55 - 64 (2018/11/23)

Monoacylglycerol lipase (MGL) inhibition provides a potential treatment approach to glaucoma through the regulation of ocular 2-arachidonoylglycerol (2-AG) levels and the activation of CB1 receptors. Herein, we report the discovery of new series of carbamates as highly potent and selective MGL inhibitors. The new inhibitors showed potent nanomolar inhibitory activity against recombinant human and purified rat MGL, were selective (>1000-fold) against serine hydrolases FAAH and ABHD6 and lacked any affinity for the cannabinoid receptors CB1 and CB2. Protein-based 1H NMR experiments indicated that inhibitor 2 rapidly formed a covalent adduct with MGL with a residence time of about 6 h. This interconversion process “intrinsic reversibility” was exploited by modifications of the ligand's size (length and bulkiness) to generate analogs with “tunable’ adduct residence time (τ). Inhibitor 2 was evaluated in a normotensive murine model for assessing intraocular pressure (IOP), which could lead to glaucoma, a major cause of blindness. Inhibitor 2 was found to decrease ocular pressure by ~4.5 mmHg in a sustained manner for at least 12 h after a single ocular application, underscoring the potential for topically-administered MGL inhibitors as a novel therapeutic target for the treatment of glaucoma.

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