7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 233272-33-8
• Molecular Formula: C₁₉H₁₈N₂O₆
• Molecular Weight: 370.362

Synonyms:7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (67123-97-1) + benzyl chloroformate (501-53-1,94274-21-2) + methyl iodide (74-88-4) → 5-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline (233272-32-7) + 7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline (233272-33-8)

Guidance literature:

With nitronium tetrafluoborate; sodium hydrogencarbonate; methyl iodide; Yield given; Multistep reaction;

DOI:10.1021/jm9807252

Reference yield: 82.0%

7-nitro-N-benzyloxycarbonyl-3-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline (233272-33-8) → 3-hydroxymethyl-7-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jm9807252

upstream raw materials:

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

benzyl chloroformate

methyl iodide

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