N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

Base Information

Chemical Name:N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide
CAS No.:1380919-33-4
Molecular Formula:C₂₆H₂₅Cl₂F₆N₅O
Molecular Weight:608.414
Hs Code.:

N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

Synonyms:N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

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Chemical Property of N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

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Technology Process of N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

There total 4 articles about N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1242269-29-9
N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide

: 1380921-08-3
5-chloro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline

: 1380919-33-4
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

Guidance literature:: N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide; 5-chloro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline; In N,N-dimethyl-formamide; at 20 ℃;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield:

: 1242269-27-7
N-(4-chloro-3-nitro-benzyl)-1-trifluoromethyl-cyclopropane carboxamide

: 1380919-33-4
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / Raney-Nickle / ethyl acetate / 20 °C / 2250.23 Torr

2.1: diisopropyl-carbodiimide / dichloromethane / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

3.2: 1 h / 90 °C

With hydrogen; diisopropyl-carbodiimide; Raney-Nickle; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1147208-82-9
4-chloro-N-methyl-2-nitro-5-(4-trifluoromethyl-piperidin-1-yl)aniline

: 1380919-33-4
N-{4-chloro-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropaneamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / platinum on activated charcoal / tetrahydrofuran; methanol / 6 h / 20 °C / 2250.23 Torr

2.1: N,N-dimethyl-formamide / 20 °C

2.2: 1 h / 90 °C

With hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;