52253-57-3

Upstream product

• 552-79-4 (-)-N-methylephedrine 
• 814-68-6 acryloyl chloride 

Downstream Products

• 133148-53-5 (5S,1'S)-5-(1'-(dibenzylamino)ethyl)dihydrofuran-2(3H)-one 
• 133148-53-5 (5R,1'S)-5-(1'-(dibenzylamino)ethyl)dihydrofuran-2(3H)-one 
• 143337-98-8 (5S,1'S)-5-(1'-(dibenzylamino)-2'-phenylethyl)dihydrofuran-2(3H)-one 
• 133148-55-7 (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one 
• 133148-54-6 (5S,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one 
• 133148-54-6 (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one 
• 15972-17-5 5-cyclohexyl-dihydrofuran-2(3H)-one 
• 53380-21-5 γ-ethyl-γ-phenyl-butyrolactone 
• 7210-42-6 (5S)-5-methyl-5-phenyldihydrofuran-2(3H)-one 
• 88314-79-8 (R)-5-methyl-5-phenyl-3,4-dihydro(5H)-furan-2-one 
• 63357-96-0 (R)-(+)-γ-nonalactone 
• 63357-97-1 (S)-γ-nonanolide 
• 112606-95-8 5-(1-phenylethyl)-2-tetrahydrofuranone 

Relevant academic research and scientific papers

One-step highly diastereoselective synthesis of γ-aminoalkyl-substituted γ-butyrolactones by an asymmetric samarium-mediated ketyl-alkene coupling reaction

The samarium(II) iodide mediated reaction of N,N-dibenzyl-protected (S)-α-amino aldehydes with (1S,2R)-N-methylephedrinyl acrylate gave the (4R, 1′S)-γ-(aminoalkyl)-γ-butyrolactones in good yields with high diastereoselectivities (up to 80% de); (4R, 1′S)γ-amino-(2-phenylethyl)-γ-butyrolactone (6a), which should be a potent precursor for γ-secretase inhibitors, was obtained with high de value.