Technology Process of (2R,3R)-N,N-diallyl-4-(benzyloxy)-3-hydroxy-2-methylbutanethioamide
There total 3 articles about (2R,3R)-N,N-diallyl-4-(benzyloxy)-3-hydroxy-2-methylbutanethioamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Cu(MeCN)4*PF6; 2,2,5,7,8-pentamethylchroman-6-ol potassium salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane;
In
tetrahydrofuran; hexane;
at -70 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja200250p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 24 h / 20 °C / Inert atmosphere
2: Lawessons reagent / tetrahydrofuran / 3 h / Inert atmosphere; Reflux
3: Cu(MeCN)4*PF6; 2,2,5,7,8-pentamethylchroman-6-ol potassium salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane / tetrahydrofuran; hexane / 48 h / -70 °C / Inert atmosphere
With
Lawessons reagent; Cu(MeCN)4*PF6; 2,2,5,7,8-pentamethylchroman-6-ol potassium salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja200250p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Lawessons reagent / tetrahydrofuran / 3 h / Inert atmosphere; Reflux
2: Cu(MeCN)4*PF6; 2,2,5,7,8-pentamethylchroman-6-ol potassium salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane / tetrahydrofuran; hexane / 48 h / -70 °C / Inert atmosphere
With
Lawessons reagent; Cu(MeCN)4*PF6; 2,2,5,7,8-pentamethylchroman-6-ol potassium salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja200250p
