methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate
CAS No.:1350916-11-8
Molecular Formula:C₁₇H₁₄Cl₂N₂O₅S
Molecular Weight:429.281
Hs Code.:

Synonyms:methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

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Chemical Property of methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

Chemical Property:

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Technology Process of methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

There total 3 articles about methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35113-88-3
N-methyl-2,4-dichloro-aniline

: 1350916-11-8
methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / dichloromethane / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

3: tin(II) chloride dihdyrate; thiophenol; triethylamine / acetonitrile / 0.08 h / 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; sodium hydride; thiophenol; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.031

Reference yield:

: 1350916-03-8
N-(2,4-dichlorophenyl)-N,4-dimethyl-3-nitrobenzenesulfonamide

: 1350916-11-8
methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

2: tin(II) chloride dihdyrate; thiophenol; triethylamine / acetonitrile / 0.08 h / 20 °C

With tin(II) chloride dihdyrate; sodium hydride; thiophenol; triethylamine; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.031

Reference yield:

: 616-83-1
4-methyl-3-nitrobenzenesulfonyl chloride

: 1350916-11-8
methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / dichloromethane / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

3: tin(II) chloride dihdyrate; thiophenol; triethylamine / acetonitrile / 0.08 h / 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; sodium hydride; thiophenol; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.031