35113-88-3

Basic information

• Product Name: N1-METHYL-2,4-DICHLOROANILINE
• Synonyms: N1-METHYL-2,4-DICHLOROANILINE;2,4-DICHLORO-N-METHYLANILINE;N-METHYL-2,4-DICHLOROANILINE
• CAS NO: 35113-88-3
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• Product Categories: Amines;C7;Nitrogen Compounds
• Mol File: 35113-88-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 28-32 °C(lit.)
• Boiling Point: 68 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.325 g/cm³
• Vapor Pressure: 0.00613mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.48±0.12(Predicted)
• CAS DataBase Reference: N1-METHYL-2,4-DICHLOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-METHYL-2,4-DICHLOROANILINE(35113-88-3)
• EPA Substance Registry System: N1-METHYL-2,4-DICHLOROANILINE(35113-88-3)

Safety Data

• Hazard Codes: T
• Statements: 25-41-43-52/53
• Safety Statements: 26-37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 2
• Hazardous Substances Data: 35113-88-3(Hazardous Substances Data)

Usage

General Description

N1-Methyl-2,4-dichloroaniline is a chemical compound with the molecular formula C7H7Cl2N. It is a derivative of aniline, with two chlorine atoms and a methyl group attached to the nitrogen atom. N1-METHYL-2,4-DICHLOROANILINE is primarily used in the manufacturing of dyes, pigments, and pharmaceuticals. It is also used as an intermediate in the production of agrochemicals, rubber chemicals, and other industrial applications. N1-Methyl-2,4-dichloroaniline is considered to be toxic and potentially harmful to human health, and appropriate safety measures should be taken when handling and using it.

InChI:InChI=1/C7H7Cl2N/c1-10-7-3-2-5(8)4-6(7)9/h2-4,10H,1H3

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 74-88-4 methyl iodide 
• 7647-01-0 hydrogenchloride 
• 4243-17-8 2,4-dichloro-N-methyl-N-nitroso-aniline 
• 67-56-1 methanol 
• 13061-96-6 dihydroxy-methyl-borane 
• 149-73-5 trimethyl orthoformate 
• 22923-00-8 N-(2,4-dichlorophenyl)-formamide 
• 932-96-7 N-methyl(p-chloroaniline) 

Downstream Products

• 1427461-82-2 C₁₁H₁₁Cl₂N₃O 
• 1364822-81-0 ethyl 4-((2,4-dichlorophenyl)(methyl)amino)-3-oxobutanoate 
• 1350916-03-8 N-(2,4-dichlorophenyl)-N,4-dimethyl-3-nitrobenzenesulfonamide 
• 1350916-22-1 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylic acid 
• 1350916-11-8 methyl 6-(N-(2,4-dichlorophenyl)-N-methylsulfamoyl)-1-hydroxy-1H-indole-2-carboxylate 
• 1189810-02-3 N-(2,4-dichlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 
• 61439-23-4 N-methyl-N-(2,4-dichlorophenyl)-N'-(2,3-dibromopropionyl)-urea 
• 61439-31-4 1-(2,4-Dichloro-phenyl)-3-(2,3-dichloro-propionyl)-1-methyl-urea 
• 55239-60-6 C₈H₆Cl₃NO 
• 93646-27-6 N-(2,4-dichlorophenyl)-N-methylacetamide 
• 4243-17-8 2,4-dichloro-N-methyl-N-nitroso-aniline 

Relevant articles and documents

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.

Selective monomethylation of anilines by Cu(OAc)2-promoted cross-coupling with MeB(OH)2

N-Methylanilines are readily synthesized in high yields through the copper(ll)-promoted coupling of anilines and methylboronic acid. This method represents a new approach for the selective monomethylation of anilines, and it is the first reported example

A convenient one pot procedure for N-methylation of aromatic amines using trimethyl orthoformate

Aromatic amines react with trimethyl orthoformate in the presence of concentrated sulfuric acid followed by acid hydrolysis to afford mono methylated amines in moderate to good yields.