4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester

Base Information

• Chemical Name: 4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester
• CAS No.: 533914-23-7
• Molecular Formula: C₂₀H₁₉Cl₂F₂NO₄
• Molecular Weight: 446.278

Synonyms:4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester

Chemical Property of 4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester

Chemical Property:

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Technology Process of 4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester

There total 1 articles about 4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-[(2,6-dichlorophenyl)amino]-5-oxopentanoate (533913-98-3) + 2,4-difluorobenzaldehyde (1550-35-2) → 4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester (533914-23-7)

Guidance literature:

ethyl 5-[(2,6-dichlorophenyl)amino]-5-oxopentanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

2,4-difluorobenzaldehyde; In tetrahydrofuran; at -60 ℃; for 4h;

Reference yield:

4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester (533914-23-7) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-((2,6-dichlorophenyl)aminocarbonyl)-2-(1-(2,4-difluorophenyl)-1-(t-butyldimethylsilyloxy)methyl)butanoic acid ethyl ester (533914-24-8)

Guidance literature:

With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 36h;

Reference yield:

4-((2,6-dichlorophenyl)aminocarbonyl)-2-((2,4-difluorophenyl)hydroxymethyl)butanoic acid ethyl ester (533914-23-7) + chloromethyl methyl ether (107-30-2) → ethyl 5-[(2,6-dichlorophenyl)amino]-2-[(2,4-difluorophenyl)(methoxymethoxy)methyl]-5-oxopentanoate (868856-49-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 50 ℃; for 1h;

upstream raw materials:

ethyl 5-[(2,6-dichlorophenyl)amino]-5-oxopentanoate

2,4-difluorobenzaldehyde

Downstream raw materials:

4-((2,6-dichlorophenyl)aminocarbonyl)-2-(1-(2,4-difluorophenyl)-1-(t-butyldimethylsilyloxy)methyl)butanoic acid ethyl ester

ethyl 5-[(2,6-dichlorophenyl)amino]-2-[(2,4-difluorophenyl)(methoxymethoxy)methyl]-5-oxopentanoate

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