Chemical Property of 2-[3-(2-Hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol
Chemical Property:
- Appearance/Colour:White crystal powder
- Vapor Pressure:1.57E-15mmHg at 25°C
- Melting Point:164-165 °C(lit.)
- Refractive Index:1.565
- Boiling Point:573.3 °C at 760 mmHg
- PKA:(1) 6.8, (2) 9.0(at 25℃)
- Flash Point:224.5 °C
- PSA：145.44000
- Density:1.326 g/cm3
- LogP:-3.23110
- Storage Temp.:Store at RT.
- Solubility.:H2O: 1 M at 20 °C, clear, colorless
- Water Solubility.:Soluble in water.
- XLogP3:-4.6
- Hydrogen Bond Donor Count:8
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:12
- Exact Mass:282.17908655
- Heavy Atom Count:19
- Complexity:183
- Purity/Quality:
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99.0%-101.0% *data from raw suppliers
1,3-Bis[tris(hydroxymethyl)methylamino]propane *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
20/21/22-36/37/38
- Safety Statements:
22-24/25-26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Nitrogen Compounds -> Amino Alcohols, Other
- Canonical SMILES:C(CNC(CO)(CO)CO)CNC(CO)(CO)CO
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Description
BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.
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Uses
BIS-TRIS Propane may be used in the following studies:As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO2).Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.As buffer during GeO2 mineralisation. BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).
