N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

Base Information

Chemical Name:N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea
CAS No.:1271302-56-7
Molecular Formula:C₃₈H₃₁BrClF₃N₄O₄S
Molecular Weight:812.107
Hs Code.:

Synonyms:N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

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Chemical Property of N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

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Technology Process of N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

There total 2 articles about N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1271302-54-5
3'-amino-3'-deoxy-β-(E)-5-(2-bromovinyl)-2'-deoxyuridine

: 23163-86-2
1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

: 1271302-56-7
N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00591f

Reference yield:

: 83894-66-0
3'-azido-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridine

: 1271302-56-7
N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / tetrahydrofuran / 24 h / 20 °C

2: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00591f

Reference yield: 75.0%

: 1271302-56-7
N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

: 1271302-58-9
5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

Guidance literature:: With sodium azide; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00591f