5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

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Chemical Name:5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
CAS No.:1271302-58-9
Molecular Formula:C₃₈H₃₀BrClF₃N₇O₄
Molecular Weight:821.053
Hs Code.:

Synonyms:5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

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Chemical Property of 5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

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Technology Process of 5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

There total 4 articles about 5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1271302-56-7
N-(3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-thiourea

: 1271302-58-9
5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

Guidance literature:: With sodium azide; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00591f

Reference yield:

: 83894-66-0
3'-azido-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridine

: 1271302-58-9
5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran / 24 h / 20 °C

2: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: sodium azide; triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium azide; triethylamine; triphenylphosphine; mercury dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00591f

Reference yield:

: 1271302-54-5
3'-amino-3'-deoxy-β-(E)-5-(2-bromovinyl)-2'-deoxyuridine

: 1271302-58-9
5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: sodium azide; triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium azide; triethylamine; mercury dichloride; In N,N-dimethyl-formamide;
DOI:10.1039/c0ob00591f