4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

Base Information

Chemical Name:4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol
CAS No.:1354286-33-1
Molecular Formula:C₃₀H₂₅F₂N₅O₂
Molecular Weight:525.558
Hs Code.:

Synonyms:4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

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Chemical Property of 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

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Technology Process of 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

There total 5 articles about 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354288-75-7
5,7-difluoro-N-(5-iodo-2-morpholinopyridin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1354286-33-1
4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 22h; Inert atmosphere;

Reference yield:

: 848579-81-7
5-iodo-2-morpholin-4-yl-pyridin-4-ylamine

: 1354286-33-1
4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / 1,2-dimethoxyethane / 103 h / 20 - 70 °C

2: tricyclohexylphosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 22 h / 90 °C / Inert atmosphere

With potassium phosphate; sodium hydride; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 23056-36-2
2-chloro-4-nitropyridine

: 1354286-33-1
4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 20 h / Reflux

2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 12 h / 2585.81 Torr

3: potassium iodide; iodine; sodium carbonate / water / 2 h / Reflux

4: sodium hydride / 1,2-dimethoxyethane / 103 h / 20 - 70 °C

5: tricyclohexylphosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 22 h / 90 °C / Inert atmosphere

With potassium phosphate; hydrogen; iodine; sodium hydride; sodium carbonate; potassium iodide; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;