(R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide

Base Information

• Chemical Name: (R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide
• CAS No.: 1240190-22-0
• Molecular Formula: C₁₈H₂₁Cl₂N₃O₄
• Molecular Weight: 414.288

Synonyms:(R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide

Chemical Property of (R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide

There total 9 articles about (R)-2-butyl-N₄-hydroxy-N₁-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide (1240190-17-3) → (R)-2-butyl-N4-hydroxy-N1-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide (1240190-22-0)

Guidance literature:

With sodium cyanide; hydroxylamine; In tetrahydrofuran; methanol; water; for 5h;

DOI:10.1007/s12272-010-0605-7

Reference yield:

3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole (6208-35-1) → (R)-2-butyl-N4-hydroxy-N1-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide (1240190-22-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 11 h / 0 - 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 8 h / 55 °C

3.1: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

4.2: -5 - 20 °C

5.1: formic acid / 7 h / 20 °C

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

7.1: sodium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 5 h

With 4-methyl-morpholine; dmap; sodium cyanide; formic acid; sodium azide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; water; hydroxylamine; ammonium chloride; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1007/s12272-010-0605-7

Reference yield:

(3-(3,4-dichlorophenyl)isoxazol-5-yl)methanamine (1240190-03-7) → (R)-2-butyl-N4-hydroxy-N1-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]succinamide (1240190-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

1.2: -5 - 20 °C

2.1: formic acid / 7 h / 20 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

4.1: sodium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 5 h

With 4-methyl-morpholine; dmap; sodium cyanide; formic acid; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydroxylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1007/s12272-010-0605-7

upstream raw materials:

3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole

(3-(3,4-dichlorophenyl)isoxazol-5-yl)methanamine

N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]methyl]-(R)-2-tert-butoxycarbonylmethylhexanamide

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