N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

Base Information

Chemical Name:N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide
CAS No.:1240190-17-3
Molecular Formula:C₁₉H₂₂Cl₂N₂O₄
Molecular Weight:413.301
Hs Code.:

Synonyms:N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

There total 8 articles about N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₁₈H₂₀Cl₂N₂O₄

: 1240190-17-3
N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 8.5h;
DOI:10.1007/s12272-010-0605-7

Reference yield:

: 6208-35-1
3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazole

: 1240190-17-3
N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 11 h / 0 - 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 8 h / 55 °C

3.1: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

4.2: -5 - 20 °C

5.1: formic acid / 7 h / 20 °C

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

With 4-methyl-morpholine; dmap; formic acid; sodium azide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; water; ammonium chloride; triethylamine; dicyclohexyl-carbodiimide; zinc; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s12272-010-0605-7

Reference yield:

: 1240190-03-7
(3-(3,4-dichlorophenyl)isoxazol-5-yl)methanamine

: 1240190-17-3
N-[[[3-(3,4-dichlorophenyl)isoxazol]-5-yl]-methyl]-(R)-2-methoxycarbonylmethylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

1.2: -5 - 20 °C

2.1: formic acid / 7 h / 20 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 8.5 h / 0 - 20 °C

With 4-methyl-morpholine; dmap; formic acid; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1007/s12272-010-0605-7