ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Base Information

Chemical Name:ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS No.:78755-91-6
Molecular Formula:C₂₃H₂₃N₃O₅
Molecular Weight:421.453
Hs Code.:

Synonyms:ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

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Chemical Property of ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

There total 4 articles about ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 865-47-4
potassium tert-butylate

: 814-49-3
diethyl chlorophosphate

: 78756-02-2
3,4-dihydro-4-(2,4-dimethoxybenzyl)-1H-1,4-benzodiazepine-2,5-dione

: 78755-91-6
ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: With acetic acid; In N-methyl-acetamide; water;

Reference yield:

: 78756-02-2
3,4-dihydro-4-(2,4-dimethoxybenzyl)-1H-1,4-benzodiazepine-2,5-dione

: 428507-28-2
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester

: 78755-91-6
ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: 3,4-dihydro-4-(2,4-dimethoxybenzyl)-1H-1,4-benzodiazepine-2,5-dione; With Dimethyl-p-toluidine; trichlorophosphate; In toluene; for 2.5h; Reflux;

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 - 20 ℃; for 1h;

With acetic acid; In water; at -30 ℃; for 0.5h; Reflux;
DOI:10.1016/j.bmcl.2009.07.153

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 78755-91-6
ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium chloride / sodium hydroxide / methanol; water; dimethyl sulfoxide

2: acetic acid / N-methyl-acetamide; water

With hydrogenchloride; sodium chloride; acetic acid; sodium hydroxide; In N-methyl-acetamide; methanol; water; dimethyl sulfoxide;