(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate
CAS No.:1445985-80-7
Molecular Formula:C₃₁H₄₀Cl₂N₄O₃S
Molecular Weight:619.656
Hs Code.:

Synonyms:(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

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Chemical Property of (R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

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Technology Process of (R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

There total 18 articles about (R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 1445985-79-4
tert-butyl N-[4-[2,5-dichloro-4-(hydroxymethyl)phenyl]butyl]carbamate

: 1445985-80-7
(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

Guidance literature:: tert-butyl N-[4-[2,5-dichloro-4-(hydroxymethyl)phenyl]butyl]carbamate; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline; With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide;

Reference yield:

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: C₁₇H₂₅Cl₂NO₅S

: 1445985-80-7
(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-47-6
tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate

: 1445985-80-7
(R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 70 °C

With hydrogenchloride; potassium carbonate; sodium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00308